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    ATCC castration resistant prostate cancer cells
    The FLJ exhibits elevated expression levels in CRPC and is associated with a poor prognosis in prostate cancer. A The microarray volcano plot indicates the most significantly upregulated lncRNAs in <t>22Rv1.</t> LncRNA-FLJ20021 (FLJ) is markedly upregulated in 22Rv1 (right panel). The red dots denote significantly upregulated lncRNAs in 22Rv1, whereas the blue dots represent significantly downregulated lncRNAs in LNCaP. Threshold: |logFC|> 2, in comparison to LNCaP, P < 0.05. B The TCGA database reveals the expression levels of FLJ in 51 normal prostate tissue samples and 489 PCa tissue samples. C Sangerbox biomedical data analysis reveals FLJ expression across various cancers, encompassing 52 normal prostate tissue samples and 495 PCa tissue samples. D qRT-PCR compared FLJ expression in normal prostate epithelial cells (RWPE-1), benign prostatic hyperplasia cells (BPH-1), androgen-dependent (LNCaP) and androgen-independent (22Rv1, C4-2, C4-2B) PCa cell lines, as well as AR-negative (PC3, <t>DU145)</t> PCa cell lines. E Representative RNA-FISH images of FLJ in 22 BPH and 50 PCa paraffin-embedded tissue samples, with a scale bar of 250 μm. F The mean fluorescence intensity of the representative RNA-FISH images was quantified using ImageJ. G RNA-FISH results in 22 BPH and 50 PCa paraffin-embedded tissue samples were quantified using ImageJ. H RNA-FISH results in 19 PCa paraffin-embedded tissue samples with pathological stages T1a-T2c and 31 samples with stages T3a-T4 were quantified using ImageJ. I RNA-FISH results in 15 PCa paraffin-embedded tissue samples with Gleason scores of 6–7 and 35 samples with scores of 8–10 were quantified using ImageJ. J Fluorescence images were scored based on mean fluorescence intensity (0–4 points) using ImageJ, and the proportion of scores was analyzed according to pathological stage (left) and Gleason score (right). K FLJ expression in 6 PCa tissues and their matched adjacent non-cancerous tissues was analyzed using qRT-PCR
    Castration Resistant Prostate Cancer Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 2875 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    castration resistant prostate cancer cells - by Bioz Stars, 2026-09
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    Images

    1) Product Images from "A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy"

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy

    Journal: Journal of Translational Medicine

    doi: 10.1186/s12967-025-06294-9

    The FLJ exhibits elevated expression levels in CRPC and is associated with a poor prognosis in prostate cancer. A The microarray volcano plot indicates the most significantly upregulated lncRNAs in 22Rv1. LncRNA-FLJ20021 (FLJ) is markedly upregulated in 22Rv1 (right panel). The red dots denote significantly upregulated lncRNAs in 22Rv1, whereas the blue dots represent significantly downregulated lncRNAs in LNCaP. Threshold: |logFC|> 2, in comparison to LNCaP, P < 0.05. B The TCGA database reveals the expression levels of FLJ in 51 normal prostate tissue samples and 489 PCa tissue samples. C Sangerbox biomedical data analysis reveals FLJ expression across various cancers, encompassing 52 normal prostate tissue samples and 495 PCa tissue samples. D qRT-PCR compared FLJ expression in normal prostate epithelial cells (RWPE-1), benign prostatic hyperplasia cells (BPH-1), androgen-dependent (LNCaP) and androgen-independent (22Rv1, C4-2, C4-2B) PCa cell lines, as well as AR-negative (PC3, DU145) PCa cell lines. E Representative RNA-FISH images of FLJ in 22 BPH and 50 PCa paraffin-embedded tissue samples, with a scale bar of 250 μm. F The mean fluorescence intensity of the representative RNA-FISH images was quantified using ImageJ. G RNA-FISH results in 22 BPH and 50 PCa paraffin-embedded tissue samples were quantified using ImageJ. H RNA-FISH results in 19 PCa paraffin-embedded tissue samples with pathological stages T1a-T2c and 31 samples with stages T3a-T4 were quantified using ImageJ. I RNA-FISH results in 15 PCa paraffin-embedded tissue samples with Gleason scores of 6–7 and 35 samples with scores of 8–10 were quantified using ImageJ. J Fluorescence images were scored based on mean fluorescence intensity (0–4 points) using ImageJ, and the proportion of scores was analyzed according to pathological stage (left) and Gleason score (right). K FLJ expression in 6 PCa tissues and their matched adjacent non-cancerous tissues was analyzed using qRT-PCR
    Figure Legend Snippet: The FLJ exhibits elevated expression levels in CRPC and is associated with a poor prognosis in prostate cancer. A The microarray volcano plot indicates the most significantly upregulated lncRNAs in 22Rv1. LncRNA-FLJ20021 (FLJ) is markedly upregulated in 22Rv1 (right panel). The red dots denote significantly upregulated lncRNAs in 22Rv1, whereas the blue dots represent significantly downregulated lncRNAs in LNCaP. Threshold: |logFC|> 2, in comparison to LNCaP, P < 0.05. B The TCGA database reveals the expression levels of FLJ in 51 normal prostate tissue samples and 489 PCa tissue samples. C Sangerbox biomedical data analysis reveals FLJ expression across various cancers, encompassing 52 normal prostate tissue samples and 495 PCa tissue samples. D qRT-PCR compared FLJ expression in normal prostate epithelial cells (RWPE-1), benign prostatic hyperplasia cells (BPH-1), androgen-dependent (LNCaP) and androgen-independent (22Rv1, C4-2, C4-2B) PCa cell lines, as well as AR-negative (PC3, DU145) PCa cell lines. E Representative RNA-FISH images of FLJ in 22 BPH and 50 PCa paraffin-embedded tissue samples, with a scale bar of 250 μm. F The mean fluorescence intensity of the representative RNA-FISH images was quantified using ImageJ. G RNA-FISH results in 22 BPH and 50 PCa paraffin-embedded tissue samples were quantified using ImageJ. H RNA-FISH results in 19 PCa paraffin-embedded tissue samples with pathological stages T1a-T2c and 31 samples with stages T3a-T4 were quantified using ImageJ. I RNA-FISH results in 15 PCa paraffin-embedded tissue samples with Gleason scores of 6–7 and 35 samples with scores of 8–10 were quantified using ImageJ. J Fluorescence images were scored based on mean fluorescence intensity (0–4 points) using ImageJ, and the proportion of scores was analyzed according to pathological stage (left) and Gleason score (right). K FLJ expression in 6 PCa tissues and their matched adjacent non-cancerous tissues was analyzed using qRT-PCR

    Techniques Used: Expressing, Microarray, Comparison, Quantitative RT-PCR, Fluorescence

    Related Articles

    Expressing:

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy
    Article Snippet: Normal human prostate epithelial cells (RWPE-1), hormone-sensitive prostate cancer cells (lncaP), castration-resistant prostate cancer cells (22Rv1, C4-2, C4-2B), and AR-negative prostate cancer cells (PC3, DU145) were purchased from the American Type Culture Collection (ATCC).. All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.

    Microarray:

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy
    Article Snippet: Normal human prostate epithelial cells (RWPE-1), hormone-sensitive prostate cancer cells (lncaP), castration-resistant prostate cancer cells (22Rv1, C4-2, C4-2B), and AR-negative prostate cancer cells (PC3, DU145) were purchased from the American Type Culture Collection (ATCC).. All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.

    Comparison:

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy
    Article Snippet: Normal human prostate epithelial cells (RWPE-1), hormone-sensitive prostate cancer cells (lncaP), castration-resistant prostate cancer cells (22Rv1, C4-2, C4-2B), and AR-negative prostate cancer cells (PC3, DU145) were purchased from the American Type Culture Collection (ATCC).. All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.

    Quantitative RT-PCR:

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy
    Article Snippet: Normal human prostate epithelial cells (RWPE-1), hormone-sensitive prostate cancer cells (lncaP), castration-resistant prostate cancer cells (22Rv1, C4-2, C4-2B), and AR-negative prostate cancer cells (PC3, DU145) were purchased from the American Type Culture Collection (ATCC).. All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.

    Fluorescence:

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy
    Article Snippet: Normal human prostate epithelial cells (RWPE-1), hormone-sensitive prostate cancer cells (lncaP), castration-resistant prostate cancer cells (22Rv1, C4-2, C4-2B), and AR-negative prostate cancer cells (PC3, DU145) were purchased from the American Type Culture Collection (ATCC).. All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.All cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium (Gibco, Shanghai, China), supplemented with 10% fetal bovine serum (FBS; Shanghai ExCell Biology, China) and 1% penicillin–streptomycin.



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    The FLJ exhibits elevated expression levels in CRPC and is associated with a poor prognosis in prostate cancer. A The microarray volcano plot indicates the most significantly upregulated lncRNAs in 22Rv1. LncRNA-FLJ20021 (FLJ) is markedly upregulated in 22Rv1 (right panel). The red dots denote significantly upregulated lncRNAs in 22Rv1, whereas the blue dots represent significantly downregulated lncRNAs in LNCaP. Threshold: |logFC|> 2, in comparison to LNCaP, P < 0.05. B The TCGA database reveals the expression levels of FLJ in 51 normal prostate tissue samples and 489 PCa tissue samples. C Sangerbox biomedical data analysis reveals FLJ expression across various cancers, encompassing 52 normal prostate tissue samples and 495 PCa tissue samples. D qRT-PCR compared FLJ expression in normal prostate epithelial cells (RWPE-1), benign prostatic hyperplasia cells (BPH-1), androgen-dependent (LNCaP) and androgen-independent (22Rv1, C4-2, C4-2B) PCa cell lines, as well as AR-negative (PC3, DU145) PCa cell lines. E Representative RNA-FISH images of FLJ in 22 BPH and 50 PCa paraffin-embedded tissue samples, with a scale bar of 250 μm. F The mean fluorescence intensity of the representative RNA-FISH images was quantified using ImageJ. G RNA-FISH results in 22 BPH and 50 PCa paraffin-embedded tissue samples were quantified using ImageJ. H RNA-FISH results in 19 PCa paraffin-embedded tissue samples with pathological stages T1a-T2c and 31 samples with stages T3a-T4 were quantified using ImageJ. I RNA-FISH results in 15 PCa paraffin-embedded tissue samples with Gleason scores of 6–7 and 35 samples with scores of 8–10 were quantified using ImageJ. J Fluorescence images were scored based on mean fluorescence intensity (0–4 points) using ImageJ, and the proportion of scores was analyzed according to pathological stage (left) and Gleason score (right). K FLJ expression in 6 PCa tissues and their matched adjacent non-cancerous tissues was analyzed using qRT-PCR

    Journal: Journal of Translational Medicine

    Article Title: A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy

    doi: 10.1186/s12967-025-06294-9

    Figure Lengend Snippet: The FLJ exhibits elevated expression levels in CRPC and is associated with a poor prognosis in prostate cancer. A The microarray volcano plot indicates the most significantly upregulated lncRNAs in 22Rv1. LncRNA-FLJ20021 (FLJ) is markedly upregulated in 22Rv1 (right panel). The red dots denote significantly upregulated lncRNAs in 22Rv1, whereas the blue dots represent significantly downregulated lncRNAs in LNCaP. Threshold: |logFC|> 2, in comparison to LNCaP, P < 0.05. B The TCGA database reveals the expression levels of FLJ in 51 normal prostate tissue samples and 489 PCa tissue samples. C Sangerbox biomedical data analysis reveals FLJ expression across various cancers, encompassing 52 normal prostate tissue samples and 495 PCa tissue samples. D qRT-PCR compared FLJ expression in normal prostate epithelial cells (RWPE-1), benign prostatic hyperplasia cells (BPH-1), androgen-dependent (LNCaP) and androgen-independent (22Rv1, C4-2, C4-2B) PCa cell lines, as well as AR-negative (PC3, DU145) PCa cell lines. E Representative RNA-FISH images of FLJ in 22 BPH and 50 PCa paraffin-embedded tissue samples, with a scale bar of 250 μm. F The mean fluorescence intensity of the representative RNA-FISH images was quantified using ImageJ. G RNA-FISH results in 22 BPH and 50 PCa paraffin-embedded tissue samples were quantified using ImageJ. H RNA-FISH results in 19 PCa paraffin-embedded tissue samples with pathological stages T1a-T2c and 31 samples with stages T3a-T4 were quantified using ImageJ. I RNA-FISH results in 15 PCa paraffin-embedded tissue samples with Gleason scores of 6–7 and 35 samples with scores of 8–10 were quantified using ImageJ. J Fluorescence images were scored based on mean fluorescence intensity (0–4 points) using ImageJ, and the proportion of scores was analyzed according to pathological stage (left) and Gleason score (right). K FLJ expression in 6 PCa tissues and their matched adjacent non-cancerous tissues was analyzed using qRT-PCR

    Article Snippet: Normal human prostate epithelial cells (RWPE-1), hormone-sensitive prostate cancer cells (lncaP), castration-resistant prostate cancer cells (22Rv1, C4-2, C4-2B), and AR-negative prostate cancer cells (PC3, DU145) were purchased from the American Type Culture Collection (ATCC).

    Techniques: Expressing, Microarray, Comparison, Quantitative RT-PCR, Fluorescence